Organometallic Compounds
![Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | MFCD28505530 | 95.0% | 234.25 g/mol | C8H18N4O4 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202088.png-250.jpg)
Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]- | 1306615-51-9 | MFCD28505530 | 95.0% | 234.25 g/mol | C8H18N4O4 | 10 MG
Aminooxy-PEG3-azide is a PEG-based bifunctional linker containing an aminooxy (oxyamine) group and an azide group. It is used as a non-cleavable three-unit PEG spacer for antibody-drug conjugate (ADC) and PROTAC synthesis, and as an azide reagent for click chemistry reactions such as CuAAC and SPAAC.
- Bifunctional aminooxy and azide groups for oxime ligation and click chemistry.
- Non-cleavable three-unit PEG spacer suitable for ADC and PROTAC linker installation.
- Purity 95.0% and molecular weight 234.25 g/mol.
- Appearance colorless to light yellow liquid for easy handling.
- Storage: pure form -20°C (stable 3 years); in solvent -80°C (6 months) or -20°C (1 month).
- Available in small pack sizes, including 10 mg for small-scale synthesis.
Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 100 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of the PROTAC SGK3 degrader-1, which is a potent SKG3 degrader.
- Polyethylene glycol (PEG)-based PROTAC linker
- Used in the synthesis of PROTAC SGK3 degrader-1
- High solubility in DMSO (≥ 100 mg/mL)
- Long-term stability in pure form at -20°C (3 years) and 4°C (2 years)
- Extended stability in solvent at -80°C (6 months) and -20°C (1 month)
Medchemexpress LLC Bis-PEG5-PFP ester | 1334177-78-4 | 100 MG
Bis-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Contains two different ligands connected by a linker.
- One ligand targets an E3 ubiquitin ligase; the other targets the protein.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
Medchemexpress LLC Tos-PEG5-Boc | 581065-94-3 | ≥97.0% | 250 MG
Tos-PEG5-Boc is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and a ligand for the target protein. It has a molecular weight of 476.58 and a chemical formula of C22H36O9S. Its appearance is a viscous liquid, colorless to light yellow.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- Viscous liquid, colorless to light yellow appearance
- For research use only
Medchemexpress LLC (S,R,S)-AHPC-C2-PEG3-BCN | 2876198-36-4 | 99.2% | 810.01 g·mol⁻¹ | C42H59N5O9S | 10 MG
(S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is a VHL E3 ligase ligand-linker conjugate used as a building block in the synthesis of PROTACs and other conjugates. It features a PEG3 spacer and a bicyclononyne (BCN) functional group to facilitate bioorthogonal conjugation and assembly of bifunctional molecules for targeted protein degradation research.
- VHL E3 ligase ligand for targeted protein degradation applications.
- PEG3 linker provides a flexible spacer for molecular conjugation.
- BCN functional group enables strain-promoted bioorthogonal click conjugation.
- Reported high purity suitable for synthetic chemistry use.
- Intended as a small-molecule building block for PROTAC assembly and conjugation workflows.
Medchemexpress LLC N-(Amino-PEG3)-N-bis(PEG4-Boc) | 2353409-57-9 | MFCD29267156 | >98% | C38H77NO17 | 50 MG
N-(Amino-PEG3)-N-bis(PEG4-Boc) is a building block and PEG linker used to synthesize various PEG-based linkers. It can easily react with activated NHS esters or carboxylic acid in the presence of EDC or HATU. The t-butyl group can be deprotected under acidic conditions, and it is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Easily reacts with activated NHS esters or carboxylic acid in the presence of EDC or HATU.
- t-butyl group can be deprotected under acidic conditions.
- Functions as a PEG-based PROTAC linker.
Medchemexpress LLC N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid | 2183440-70-0 | 99.6% | C24H47N5O11 | 25 MG
N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It acts as a versatile click chemistry reagent, facilitating selective degradation of target proteins via the intracellular ubiquitin-proteasome system.
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
- Functions as a PROTAC linker
- Utilized in PROTAC synthesis
Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | MFCD23726612 | >98.0% | 335.35 g/mol | C13H25N3O7 | 100 MG
Azido-PEG5-acid is an azide-terminated polyethylene glycol (PEG5) linker designed for click chemistry and bioconjugation. It features a terminal carboxylic acid and an azide functional group that enable copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC), making it useful for PROTAC construction, ADC linker assembly, and general spacer chemistry.
- Azide-terminated PEG5 spacer for bioconjugation
- Compatible with CuAAC and SPAAC click reactions
- High purity for reliable coupling
- Colorless to light yellow liquid, easy to handle
- Stable under recommended storage conditions
Medchemexpress LLC Bis-PEG5-acid 10g | 439114-13-3 | 338.35 g/mol | C14H26O9 | 10 G
Bis-PEG5-acid is a polyethylene glycol (PEG) linker with two terminal carboxylic acid groups used to assemble PROTACs and other bifunctional molecules. The hydrophilic spacer increases aqueous solubility and provides flexible separation between ligands for conjugation chemistry.
- Two terminal carboxylic acid groups for conjugation.
- Hydrophilic PEG spacer improves solubility in aqueous media.
- Flexible linker suitable for PROTAC and bifunctional molecule assembly.
- Available in multiple package sizes including 10 G.
- Solid material with white to yellow appearance.
Medchemexpress LLC 3,6,9,12,15-Pentaoxaheptadecane, 1,17-diazido- | 356046-26-9 | 100.0% | 332.36 | 250 MG
Azido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group. It can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. This product is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Reacts with alkyne-containing molecules
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Reacts with molecules containing DBCO or BCN groups
Medchemexpress LLC NH2-PEG5-C6-Cl hydrochloride | 2241669-16-7 | 98.0% | 100 MG
NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase
- The other ligand targets a specific protein
- Leverages the intracellular ubiquitin-proteasome system
- For selective degradation of target proteins
Medchemexpress LLC Azido-PEG3-C6-Cl | 1625717-44-3 | 95.30% | 293.79 | 25 MG
Azido-PEG3-C6-Cl is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a click chemistry reagent, capable of undergoing both copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne groups and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Contains an azide group
- Participates in CuAAc reactions with alkyne groups
- Undergoes SPAAC reactions with DBCO or BCN groups
Medchemexpress LLC (S,R,S)-AHPC-PEG3-NH2 hydrochloride | 2097971-11-2 | MFCD31656714 | 99.0% | 656.23 g/mol | C30H46ClN5O7S | 1 G
(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a VHL E3 ligase ligand-linker conjugate that combines a stereodefined AHPC VHL ligand with a three-unit polyethylene glycol linker terminating in a primary amine. Supplied as the hydrochloride salt, it is intended as a research building block for PROTAC synthesis and other chemical biology applications.
- Hydrochloride salt form for improved handling.
- Primary amine terminus suitable for common coupling chemistries.
- Three-unit PEG linker provides aqueous solubility and flexible spacing.
- Stereochemically defined (S,R,S) VHL ligand for targeted E3 ligase engagement.
- High reported purity (~99.0%) for reliable synthetic use.
- Available in small to gram-scale quantities for research workflows.
Medchemexpress LLC BnO-PEG5-OH | 57671-28-0 | 98.6% | 328.40 g/mol | C17H28O6 | 10 G
BnO-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker used to connect ligands in proteolysis targeting chimera (PROTAC) synthesis, providing spacer functionality and flexibility to aid target engagement and E3 ligase recruitment.
- Polyethylene glycol spacer with five ethylene glycol units.
- High purity suitable for research applications.
- Liquid, colorless to light yellow, density ≈ 1.10 g/cm3.
- Stable under recommended storage conditions for pure material and in solvent.
- Available in common laboratory pack sizes, including 10 g.